Investigating how genetic changes in RNA modifications affect immune diseases
Official title: Genetic variation of N6-methyladenosine (m6A) RNA modification in immune cells and its contribution to human diseases
Funded at University of Chicago · NIH-10999470 · Data updated 2026-11-12
This study is looking at how certain genetic differences affect immune cells and may play a role in diseases like asthma and Alzheimer's, with the hope of finding new ways to improve treatments based on your unique genetics.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | December 11, 2023 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $755,042 |
| NIH project number | 5R01AI175554-02 |
| Project ID | NIH-10999470 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with immune-related conditions such as asthma or Alzheimer's disease.
✕Less likely to help
Patients with non-immune-related conditions or those without genetic variations affecting RNA modifications may not benefit from this research.
What this research studies
This research focuses on understanding how genetic variations in N6-methyladenosine (m6A) RNA modifications influence immune cell functions and contribute to diseases like asthma and Alzheimer's. By utilizing genome-wide association studies (GWAS), the project aims to identify risk variants and genes associated with immune disorders. The researchers will explore the role of m6A modifications in RNA processing, which may reveal new therapeutic targets for these conditions. Patients may benefit from insights that could lead to improved treatments based on their genetic profiles.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for immune-related diseases by identifying genetic factors that influence disease risk.
How similar studies have gone: Previous research has successfully identified genetic variants associated with immune diseases, suggesting that this approach has the potential for meaningful discoveries.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: He, Xin — University of Chicago
- Study coordinator: He, Xin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.