Investigating how genetic changes affect brain function and mental health.
Methods for single-cell CRISPR screens and multiomic data: constructing powerful well-calibrated tests, circumventing unmeasured confounding, and accounting for denoising and imputation
['FUNDING_R01'] · CARNEGIE-MELLON UNIVERSITY · NIH-11063275
This study is looking at how differences in our genes affect brain cells and can lead to mental health problems, using cutting-edge technology to find better ways to understand and treat these issues, which could help patients get more accurate diagnoses and personalized treatments.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CARNEGIE-MELLON UNIVERSITY (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11063275 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how genetic variations influence gene activity in specific brain cells, which can lead to mental health issues. By using advanced CRISPR technology, the researchers aim to develop new methods to analyze how genes work together in different cell types and conditions. The study will integrate data from single cells and tissues to create a clearer picture of the genetic factors contributing to psychopathology. Patients may benefit from improved diagnostic tools and targeted therapies based on these findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic predispositions to mental health conditions or those experiencing related symptoms.
Not a fit: Patients without any genetic risk factors for psychopathology or those not experiencing mental health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for mental health disorders.
How similar studies have performed: Other research utilizing CRISPR technology for genetic analysis has shown promising results, indicating potential for success in this approach.
Where this research is happening
PITTSBURGH, UNITED STATES
- CARNEGIE-MELLON UNIVERSITY — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ROEDER, KATHRYN M — CARNEGIE-MELLON UNIVERSITY
- Study coordinator: ROEDER, KATHRYN M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.