Investigating how genetic changes affect appetite regulation in the nervous system
Alternative polyadenylation as a genetic regulatory mechanism to bridge genome to phenome in the nervous system
['FUNDING_OTHER'] · UNIVERSITY OF WASHINGTON · NIH-10891744
This study is looking at how our genes affect our appetite and could help people with eating disorders like anorexia or obesity by finding new ways to treat these conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10891744 on ClinicalTrials.gov |
What this research studies
This research explores the genetic mechanisms that influence appetite regulation in the brain, particularly focusing on conditions like anorexia nervosa and obesity. It examines how changes in RNA processing, specifically alternative polyadenylation, can affect gene expression related to appetite control. By understanding these genetic processes, the research aims to uncover potential targets for therapeutic interventions that could help manage eating disorders and obesity. Patients may benefit from insights that could lead to new treatment options for appetite-related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from anorexia nervosa, obesity, or related appetite disorders.
Not a fit: Patients with appetite disorders not related to genetic factors or those without significant appetite regulation issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for managing anorexia and obesity by targeting genetic mechanisms that regulate appetite.
How similar studies have performed: Previous research has shown promising results in understanding genetic factors influencing appetite, suggesting that this approach could yield valuable insights.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRUTMAN, JULIANNA NICOLE — UNIVERSITY OF WASHINGTON
- Study coordinator: BRUTMAN, JULIANNA NICOLE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Appetite Disorder