Investigating how genes interact with ethanol to cause birth defects
Official title: Genetic screens in zebrafish to identify gene-ethanol interactions
Funded at University of Texas at Austin · NIH-10882451 · Data updated 2026-11-12
This study is looking at how genes might affect the risks of birth defects caused by drinking alcohol during pregnancy, using zebrafish to learn more about how these factors work together, with the hope of finding better ways to prevent and treat Fetal Alcohol Spectrum Disorder (FASD).
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas at Austin NIH-funded |
| Lab location | 1 site (Austin, United States) |
| Project start | August 20, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $351,554 |
| NIH project number | 2R01AA023426-06A1 |
| Project ID | NIH-10882451 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pregnant individuals or those planning to become pregnant, particularly those with a history of alcohol use.
✕Less likely to help
Patients who are not pregnant or do not have a history of alcohol exposure may not benefit from this research.
What this research studies
This research focuses on understanding how genetic factors influence the effects of ethanol exposure during pregnancy, which can lead to serious birth defects, particularly affecting the nervous system. Using zebrafish embryos, the researchers will explore how reactive oxygen species (ROS) and specific signaling pathways affect the teratogenic effects of ethanol. The study aims to identify genetic loci that may increase or decrease the risk of developing Fetal Alcohol Spectrum Disorder (FASD). By uncovering these interactions, the research hopes to provide insights that could lead to better prevention and treatment strategies for affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention of birth defects caused by fetal alcohol exposure.
How similar studies have gone: Previous research has shown success in using zebrafish models to study genetic interactions and teratogenic effects, indicating a promising approach.
Where this research is happening
-
University of Texas at Austin
Austin, United States Active
Researchers
- Principal investigator: Eberhart, Johann K — University of Texas at Austin
- Study coordinator: Eberhart, Johann K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.