Investigating how genes influence addiction to nicotine and cannabis through brain connectivity
Official title: A novel transcriptome-connectome approach to study the neurogenetic mechanism of nicotine and cannabis addiction
Funded at Univ of Maryland, College Park · NIH-10984753 · Data updated 2026-11-12
This study is looking at how our genes might influence addiction to things like nicotine and cannabis by checking how different parts of the brain connect with each other, and it's for anyone who wants to understand more about why some people struggle with addiction and how we can help them better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Maryland, College Park NIH-funded |
| Lab location | 1 site (College Park, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $175,888 |
| NIH project number | 1K01DA059603-01A1 |
| Project ID | NIH-10984753 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of nicotine or cannabis use disorders.
✕Less likely to help
Patients who do not use nicotine or cannabis or have no history of substance use disorders may not benefit from this research.
What this research studies
This research explores the genetic factors that contribute to addiction to substances like nicotine and cannabis by examining brain connectivity patterns. Using advanced neuroimaging techniques, the study aims to understand how genetic variations affect brain function and structure in individuals with substance use disorders. By analyzing large datasets that include genetic information and brain imaging, the research seeks to clarify the relationship between genes, brain changes, and addictive behaviors. The findings could lead to better understanding and treatment options for those struggling with addiction.
Why it matters
Potential benefit: If successful, this research could provide insights that lead to more effective treatments for nicotine and cannabis addiction.
How similar studies have gone: Previous research has shown promising results in understanding addiction through genetic and neuroimaging approaches, indicating that this study builds on established methodologies.
Where this research is happening
-
Univ of Maryland, College Park
College Park, United States Active
Researchers
- Principal investigator: Ma, Tianzhou — Univ of Maryland, College Park
- Study coordinator: Ma, Tianzhou
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.