Investigating how genes control the development of hearing cells in the inner ear.
A CRISPR-based toolkit for investigating hair cell transcription factors in inner ear organoids
This study is exploring how certain genes help create the tiny hair cells in the inner ear that are crucial for hearing, using a special lab model, and it aims to find new ways to treat hearing loss that could help patients in the future.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10947953 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific genes, known as transcription factors, influence the development of hair cells in the inner ear, which are essential for hearing. Using a new model that grows inner ear organoids from mouse embryonic stem cells, researchers will apply CRISPR technology to activate or inhibit these genes. This approach allows for a detailed examination of how these cells develop and could lead to breakthroughs in regenerative therapies for hearing loss. Patients may benefit from insights gained that could lead to new treatments for conditions affecting hearing.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with hearing loss or conditions that affect the inner ear, particularly those who are 21 years or older.
Not a fit: Patients with hearing loss due to non-genetic factors or those who are younger than 21 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that restore hearing by promoting the regeneration of hair cells in the inner ear.
How similar studies have performed: Other research has shown promise using CRISPR technology for gene activation in various contexts, suggesting potential success in this novel application for inner ear cell development.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Matern, Maggie S. — Stanford University
- Study coordinator: Matern, Maggie S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.