Investigating how genes control serotonin neuron function in the brain
Brain serotonin neuron gene regulatory networks and chromatin architecture
['FUNDING_R01'] · CASE WESTERN RESERVE UNIVERSITY · NIH-10739286
This study is looking at how certain genes in serotonin neurons, which are important for our mood and brain health, are controlled during different stages of brain development, to help us understand their role in conditions like depression and anxiety.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10739286 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the molecular mechanisms that regulate gene expression in serotonin neurons, which are crucial for brain health and function. By studying specific transcription factors that control gene expression during different stages of neuronal development, the research aims to uncover how these processes are linked to various neuropsychiatric disorders such as depression and anxiety. The approach involves detailed analysis of gene regulatory networks and chromatin architecture in serotonin neurons, using advanced techniques to observe changes in gene expression over time. This could provide insights into how serotonin-related genes are regulated and their impact on mental health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing neuropsychiatric disorders such as depression, anxiety, autism, OCD, or schizophrenia.
Not a fit: Patients with neuropsychiatric disorders not related to serotonin dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating neuropsychiatric disorders linked to serotonin dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding gene regulation in neurons, suggesting that this approach could yield valuable insights.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DENERIS, EVAN S — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: DENERIS, EVAN S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.