Investigating how genes are spliced in the mouse inner ear at a single cell level
Official title: Alternative splicing in the mouse inner ear at single cell resolution
Funded at Vanderbilt University Medical Center · NIH-10975182 · Data updated 2026-11-12
This study is looking at how certain genes work in the inner ear of mice to help us understand hearing loss and balance problems, with the hope that this knowledge can lead to better treatments for people who experience these issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $218,750 |
| NIH project number | 1R21DC022058-01 |
| Project ID | NIH-10975182 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing sensorineural hearing loss or vestibular dysfunction.
✕Less likely to help
Patients with purely conductive hearing loss or those without any inner ear dysfunction may not benefit from this research.
What this research studies
This research focuses on understanding the molecular mechanisms behind sensorineural hearing loss and vestibular dysfunction by examining alternative splicing in the inner ear of mice. Using advanced single-cell RNA sequencing technology, the study aims to uncover the genetic diversity and regulatory processes that occur in the inner ear's cells. By identifying how genes are spliced differently in various cell types, the research seeks to provide insights into the development and function of the auditory and balance systems. This knowledge could lead to better therapeutic strategies for hearing and balance disorders.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for individuals suffering from hearing loss and balance disorders.
How similar studies have gone: Previous research has shown promise in understanding gene regulation through alternative splicing, but this specific approach in the inner ear is relatively novel.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Jan, Taha a — Vanderbilt University Medical Center
- Study coordinator: Jan, Taha a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.