Investigating how genes are affected by traumatic brain injury and environmental exposures.
CSR&D Research Career Scientist Award Application
This study is looking at how brain changes from traumatic injuries, especially in veterans who have experienced blasts, might affect mental health and increase the risk of suicide, with the hope of improving care for those who need it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | James J Peters VA Medical Center NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-10924644 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of medical epigenetics in traumatic brain injury (TBI) and its connection to suicidal behavior. By analyzing human brain samples, the study examines how genes are regulated differently due to environmental factors, particularly in veterans exposed to blasts. The research aims to uncover the long-term effects of these injuries on mental health, including anxiety, cognitive deficits, and PTSD. Through this work, the goal is to enhance clinical care for veterans by identifying the biological mechanisms that contribute to suicide risk.
Who could benefit from this research
Good fit: Ideal candidates for this research include veterans who have experienced traumatic brain injuries or blast exposures during military service.
Not a fit: Patients who have not experienced any form of traumatic brain injury or related environmental exposures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for veterans suffering from TBI and related mental health issues.
How similar studies have performed: Previous research has shown promising results in understanding the epigenetic changes associated with traumatic brain injuries, indicating that this approach has potential for significant insights.
Where this research is happening
Bronx, United States
- James J Peters VA Medical Center — Bronx, United States (Active)
Researchers
- Principal investigator: Haghighi, Fatemeh G — James J Peters VA Medical Center
- Study coordinator: Haghighi, Fatemeh G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.