Investigating how genes and sex differences affect heart failure with preserved ejection fraction.
Gene-by-sex interactions in heart failure with preserved ejection fraction (HFpEF)
This study is looking at how genes and differences between men and women affect heart failure with preserved ejection fraction (HFpEF), especially since it seems to be more common in women, and it uses mouse models to see how diet and other factors influence heart health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10919842 on NIH RePORTER |
What this research studies
This research explores the interactions between genetic factors and sex differences in patients with heart failure with preserved ejection fraction (HFpEF). By using a system genetics approach, the study integrates clinical and molecular traits to understand how these factors contribute to the development and severity of HFpEF. The research utilizes mouse models to simulate the condition, focusing on the impact of diet and other environmental factors on heart function. The goal is to uncover the underlying mechanisms that lead to the higher prevalence of HFpEF in women compared to men.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with heart failure with preserved ejection fraction, especially women who may experience more severe symptoms.
Not a fit: Patients with heart failure with reduced ejection fraction or those without any heart failure diagnosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment strategies for heart failure patients, particularly addressing the unique needs of women.
How similar studies have performed: Previous research has shown promising results in understanding sex differences in cardiovascular diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Lusis, Aldons Jake — University of California Los Angeles
- Study coordinator: Lusis, Aldons Jake
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.