Investigating how genes and environmental toxins affect eyelid development
Gene-environment interactions in epithelial morphogenesis
This study is looking at how certain genes and harmful chemicals in the environment might work together to cause birth defects, using mice to understand how these factors affect the development of eyelids in embryos.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10619541 on NIH RePORTER |
What this research studies
This research explores the interactions between genetic factors and environmental pollutants, specifically dioxin-like chemicals, that may lead to birth defects. Using a mouse model, the study focuses on how certain gene mutations can make developing tissues more susceptible to the harmful effects of these toxins. By examining the process of eyelid closure during embryonic development, researchers aim to uncover the genetic and signaling pathways involved in this critical morphogenetic event. The findings could provide insights into the mechanisms that contribute to congenital abnormalities caused by environmental exposures.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of congenital abnormalities or those concerned about the effects of environmental toxins during pregnancy.
Not a fit: Patients who do not have a history of congenital defects or are not exposed to dioxin-like chemicals may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention of birth defects related to environmental exposures.
How similar studies have performed: Other research has shown success in understanding gene-environment interactions in developmental processes, making this approach promising.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Xia, Ying — University of Cincinnati
- Study coordinator: Xia, Ying
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.