Investigating how genes and environmental factors interact in Parkinson's disease
An in vivo multiplex model to study gene-environment interaction in Parkinson's Disease
This study is looking at how our genes and the environment work together to affect Parkinson's disease, using fruit flies to see how human genes respond to toxins, with the hope of finding new ways to help manage the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10875466 on NIH RePORTER |
What this research studies
This research explores the complex interactions between genetic factors and environmental influences that may contribute to Parkinson's disease. Using a unique model involving fruit flies, the study examines how human genes related to Parkinson's interact with environmental toxins. The researchers aim to identify potential drug targets that could help mitigate these interactions. By combining advanced microscopy techniques and human-derived neurons, the project seeks to uncover new insights into the mechanisms behind Parkinson's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 who are at risk for or diagnosed with Parkinson's disease.
Not a fit: Patients with Parkinson's disease who do not have genetic risk factors or environmental exposures related to the study may not benefit.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better address the causes of Parkinson's disease by targeting gene-environment interactions.
How similar studies have performed: While the approach of studying gene-environment interactions is gaining traction, this specific multiplex model using Drosophila is relatively novel and has not been extensively tested in prior research.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Sarkar, Souvarish — University of Rochester
- Study coordinator: Sarkar, Souvarish
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.