Investigating how genes and environment affect social and emotional behavior
Epigenetic involvement in socio-emotional behavior studied by PET- MRI
['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-11089607
This study is looking at how certain enzymes in the brain might affect our emotions and social behaviors, and it's for healthy young adults who want to help researchers understand how these factors can differ between men and women.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11089607 on ClinicalTrials.gov |
What this research studies
This research explores the role of histone deacetylases (HDACs), enzymes that influence gene expression, in shaping socio-emotional behavior. Using advanced PET imaging technology, the study aims to assess HDAC expression in the brains of healthy young adults and correlate it with various neuropsychological traits such as emotion regulation and anxiety. The research will also examine potential differences in HDAC expression between males and females. By understanding these relationships, the study seeks to shed light on how genetic and environmental factors contribute to emotional and social functioning.
Who could benefit from this research
Good fit: Ideal candidates for participation are healthy young adults aged 21 and under, including both males and females.
Not a fit: Patients with existing psychiatric disorders or those outside the age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the biological underpinnings of emotional and social behaviors, potentially informing treatments for related psychiatric conditions.
How similar studies have performed: Previous research has shown promising results in understanding the role of HDACs in brain function, but this specific approach using PET imaging is relatively novel.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZURCHER WIMMER, NICOLE R — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: ZURCHER WIMMER, NICOLE R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: autism spectral disorder