Investigating how genes and environment affect lung function in children with asthma
Official title: Methylomic and metabolomic determinants of Lung Function in Asthmatics
Funded at Rutgers Biomedical and Health Sciences · NIH-11079982 · Data updated 2026-11-12
This study is looking at how changes in DNA and certain substances in the body affect lung health in children with asthma, to help us understand how the environment might influence their condition and improve asthma care for kids.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | July 1, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 4R00HL159234-03 |
| Project ID | NIH-11079982 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-20 years who have been diagnosed with asthma.
✕Less likely to help
Patients who do not have asthma or are outside the age range of 0-20 years may not benefit from this research.
What this research studies
This research explores the relationship between DNA methylation and metabolites in children with asthma to understand how environmental factors influence lung function. By analyzing data from large childhood cohorts, the study aims to uncover specific pathways that may affect asthma progression and lung health. The approach integrates genetic, methylomic, and metabolomic data to provide a comprehensive view of the factors impacting lung function in asthmatic children. This could lead to better understanding and management of asthma in young patients.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing asthma and enhancing lung function in children.
How similar studies have gone: While previous studies have looked at either the methylome or metabolome in relation to lung function, this research is novel as it investigates both simultaneously.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Kachroo, Priyadarshini — Rutgers Biomedical and Health Sciences
- Study coordinator: Kachroo, Priyadarshini
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.