Investigating how genes and environment affect Alzheimer's risk and resilience throughout life
Official title: Gene-environment Interplay Among Modifiable Factors for AD/ADRD: Risk and Resilience Across the Lifespan
Funded at University of Colorado · NIH-11143071 · Data updated 2026-11-12
This study is looking at how our genes and the environment around us can affect the chances of developing Alzheimer's and related memory issues throughout our lives, and it’s for anyone interested in understanding how lifestyle choices and genetics can impact brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado NIH-funded |
| Lab location | 1 site (Boulder, UNITED STATES) |
| Project start | August 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $732,466 |
| NIH project number | 5R01AG089666-02 |
| Project ID | NIH-11143071 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of Alzheimer's disease or those concerned about their cognitive health as they age.
✕Less likely to help
Patients who are currently diagnosed with advanced Alzheimer's disease or related dementias may not benefit from this research.
What this research studies
This research examines the interplay between genetic and environmental factors that may influence the risk of developing Alzheimer's disease and related dementias (AD/ADRD) across different stages of life. By utilizing data from twin studies, the project aims to identify modifiable risk factors and understand when these risks are most significant. The study will analyze longitudinal data and polygenic scores to create comprehensive risk profiles, which could inform prevention and intervention strategies for AD/ADRD. Participants may contribute to a better understanding of how lifestyle and genetic predispositions interact to affect cognitive health.
Why it matters
Potential benefit: If successful, this research could lead to targeted prevention strategies that reduce the risk of Alzheimer's disease and related dementias.
How similar studies have gone: Previous research has shown promise in understanding gene-environment interactions in cognitive health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Colorado
Boulder, United States Active
Researchers
- Principal investigator: Reynolds, Chandra a — University of Colorado
- Study coordinator: Reynolds, Chandra a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.