Investigating how genes and environment affect Alzheimer's risk and resilience throughout life
Gene-environment Interplay Among Modifiable Factors for AD/ADRD: Risk and Resilience Across the Lifespan
This study is looking at how our genes and the environment around us can affect the chances of developing Alzheimer's and related memory issues throughout our lives, and it’s for anyone interested in understanding how lifestyle choices and genetics can impact brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado NIH-funded |
| Lab location | 1 site (Boulder, UNITED STATES) |
| Project ID | NIH-11143071 on NIH RePORTER |
What this research studies
This research examines the interplay between genetic and environmental factors that may influence the risk of developing Alzheimer's disease and related dementias (AD/ADRD) across different stages of life. By utilizing data from twin studies, the project aims to identify modifiable risk factors and understand when these risks are most significant. The study will analyze longitudinal data and polygenic scores to create comprehensive risk profiles, which could inform prevention and intervention strategies for AD/ADRD. Participants may contribute to a better understanding of how lifestyle and genetic predispositions interact to affect cognitive health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of Alzheimer's disease or those concerned about their cognitive health as they age.
Not a fit: Patients who are currently diagnosed with advanced Alzheimer's disease or related dementias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted prevention strategies that reduce the risk of Alzheimer's disease and related dementias.
How similar studies have performed: Previous research has shown promise in understanding gene-environment interactions in cognitive health, suggesting that this approach could yield valuable insights.
Where this research is happening
Boulder, UNITED STATES
- University of Colorado — Boulder, United States (Active)
Researchers
- Principal investigator: Reynolds, Chandra a — University of Colorado
- Study coordinator: Reynolds, Chandra a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.