Investigating how genes affect the branching of nerve cells in tiny worms.
Official title: Genetic Analyses of Dendrite Morphogenesis in Caenorhabditis Elegans
Funded at Albert Einstein College of Medicine · NIH-11093442 · Data updated 2026-11-12
This study is looking at how certain genes affect the growth of tiny branches on nerve cells, which are important for how our brains work, and it uses a small worm to help find clues that could improve our understanding of conditions like autism.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $435,557 |
| NIH project number | 5R01NS129992-03 |
| Project ID | NIH-11093442 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with autism spectrum disorder or related neurological conditions.
✕Less likely to help
Patients with conditions unrelated to genetic factors affecting neural development may not benefit from this research.
What this research studies
This research focuses on understanding the genetic and molecular mechanisms that control the development of dendrites, which are essential for proper neural circuit function. Using the model organism Caenorhabditis elegans, the study examines specific neurons to identify genes that influence dendrite branching. By conducting genetic screens, researchers aim to uncover how certain genes restrict or promote dendrite formation, which could provide insights into broader neurological processes. The findings may help in understanding conditions like autism spectrum disorder by revealing fundamental aspects of neural development.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic factors that contribute to neurological conditions, potentially informing future treatments.
How similar studies have gone: While this research explores specific genetic mechanisms in a model organism, similar studies have shown promise in understanding neural development and disorders.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Buelow, Hannes Erich — Albert Einstein College of Medicine
- Study coordinator: Buelow, Hannes Erich
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.