Investigating how genes affect resilience to toxic chemicals
CRISPR screens of population relevant genes governing toxicant resilience
This study is looking at how our genes might make some people more sensitive to harmful chemicals and toxins, so we can better understand who might be at risk and find ways to help keep them healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10988258 on NIH RePORTER |
What this research studies
This research explores how genetic differences among individuals influence their responses to harmful chemicals and biological toxins. By identifying specific genes that interact with these toxicants, the study aims to uncover why some people are more susceptible to adverse health effects than others. The researchers will focus on a set of 1490 genes known to be involved in the body's response to toxins, using advanced genetic screening techniques to pinpoint key variants that may contribute to resilience or vulnerability. This approach could lead to better identification of at-risk populations and inform preventive health strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with known sensitivities to environmental toxins or those with a family history of adverse reactions to chemical exposures.
Not a fit: Patients who have no history of exposure to toxicants or those without genetic predispositions to adverse reactions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for identifying individuals at risk of adverse effects from toxic exposures, enabling targeted prevention strategies.
How similar studies have performed: While the approach of using genetic screening to understand toxicant resilience is innovative, similar studies have shown promise in identifying genetic factors related to environmental health risks.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Vulpe, Christopher D — University of Florida
- Study coordinator: Vulpe, Christopher D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.