Investigating how genes affect behavior using a small worm model.
Molecular coordination of adhesion molecules in foraging behaviors and circuits
This study looks at how certain genes affect the behavior and brain connections in tiny worms, which can help us learn more about how similar genes might influence behavior in people with conditions like autism.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10895513 on NIH RePORTER |
What this research studies
This research explores the roles of specific genes in the behavior and brain circuits of the small nematode C. elegans, a model organism that allows for detailed genetic analysis. By examining how these genes interact and contribute to behavioral changes, the study aims to uncover fundamental mechanisms that may also apply to neurodevelopmental disorders like autism. The research employs advanced techniques to analyze multiple genes and their effects on various behaviors simultaneously, providing insights into neuronal plasticity and gene function. This work could lead to a better understanding of how genetic factors influence behavior in more complex organisms, including humans.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research are individuals with neurodevelopmental disorders, particularly those with autism spectrum disorder.
Not a fit: Patients with behavioral disorders not linked to genetic factors or those without neurodevelopmental conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of the genetic basis of behavioral disorders, potentially leading to new therapeutic strategies for conditions like autism.
How similar studies have performed: Other research has shown success in using model organisms like C. elegans to uncover genetic mechanisms related to behavior, indicating that this approach is both promising and validated.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Hart, Michael P — University of Pennsylvania
- Study coordinator: Hart, Michael P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.