Investigating how gene regulation changes in individual brain cells over time
Studying the Regulatory Dynamics with Single-cell Multiomics
This study is looking at how aging affects the way brain cells work and express their genes, which could help us understand neurodegenerative diseases better and lead to new treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York Genome Center NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10686569 on NIH RePORTER |
What this research studies
This research focuses on understanding the complex mechanisms that regulate gene expression in individual brain cells, particularly as they age. By utilizing advanced single-cell multiomics technologies, the study aims to capture both the static and dynamic aspects of gene regulation, which are crucial for understanding neurodegenerative diseases. Patients may benefit from insights into how aging affects brain cell function and the potential development of targeted therapies. The research will analyze various molecular layers to uncover how these changes contribute to neurological conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing early signs of neurodegeneration or those at risk due to age or genetic factors.
Not a fit: Patients with acute neurological injuries or conditions unrelated to neurodegeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating neurodegenerative diseases by targeting the underlying mechanisms of gene regulation in aging brain cells.
How similar studies have performed: Other research has shown promising results in understanding gene regulation in single cells, suggesting that this approach could yield valuable insights into neurodegenerative diseases.
Where this research is happening
New York, United States
- New York Genome Center — New York, United States (Active)
Researchers
- Principal investigator: Zhu, Chenxu — New York Genome Center
- Study coordinator: Zhu, Chenxu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.