Investigating how gene interactions with tobacco carcinogens affect lung cancer risk
Official title: Gene-tobacco carcinogen interactions and lung cancer risk - a novel approach for precision cancer prevention
Funded at State University of New York at Buffalo · NIH-11240741 · Data updated 2026-11-12
This study is looking at how certain genes and tobacco chemicals work together to affect the risk of lung cancer in smokers, and it will help identify people who might be more at risk based on their unique body responses to tobacco.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project start | December 16, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $615,223 |
| NIH project number | 7R01CA269223-03 |
| Project ID | NIH-11240741 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include smokers and former smokers who may have genetic variations affecting their metabolism of tobacco carcinogens.
✕Less likely to help
Patients who have never smoked or do not have genetic markers related to tobacco carcinogen metabolism may not benefit from this research.
What this research studies
This research focuses on understanding how specific genetic factors interact with tobacco-related carcinogens to influence lung cancer risk. It examines the metabolism of a tobacco-specific nitrosamine, NNK, and its metabolites, particularly NNAL, in smokers. By analyzing urine samples and genetic markers, the study aims to identify individuals at higher risk for lung cancer based on their unique biological responses to tobacco exposure. The research will involve multiple populations to ensure diverse representation and robust findings.
Why it matters
Potential benefit: If successful, this research could lead to personalized prevention strategies for lung cancer based on genetic susceptibility to tobacco carcinogens.
How similar studies have gone: Previous research has shown promising results in identifying genetic markers associated with cancer risk, suggesting that this approach could yield valuable insights.
Where this research is happening
-
State University of New York at Buffalo
Amherst, United States Active
Researchers
- Principal investigator: Lazarus, Philip — State University of New York at Buffalo
- Study coordinator: Lazarus, Philip
Related research
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Integrative Analysis of Lung Cancer Risk and Causes
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.