Investigating how gene expression regulation affects breast cancer progression
Biological and cancer-associated role of epitranscriptomic gene expression regulation
This study is looking at how a gene called NNMT affects triple-negative breast cancer by changing important molecules in the cells, and it hopes to find new ways to help treat this type of cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10984482 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a specific gene, NNMT, in triple-negative breast cancer (TNBC). It examines how high levels of NNMT can lead to changes in gene expression by depleting a key molecule called S-adenosyl methionine (SAM), which is crucial for DNA and RNA modifications. By studying patient-derived cancer cell lines, the research aims to uncover the mechanisms by which NNMT influences cancer progression and the potential implications for treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with triple-negative breast cancer, particularly those with aggressive tumor characteristics.
Not a fit: Patients with non-breast cancers or those with early-stage breast cancer may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for treating aggressive forms of breast cancer.
How similar studies have performed: Previous research has shown promising results in understanding the role of RNA modifications in cancer, indicating that this approach has potential for success.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Dolcen, Deniz Nesli — Stanford University
- Study coordinator: Dolcen, Deniz Nesli
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.