Investigating how gene expression is regulated in mammalian tissues
Tissue biology studies of histone modification, nascent transcription, and post-transcription regulation
This study is looking at how cells in your skin control the activity of genes, especially when they grow and heal, to help us understand how hair follicles work and how they change when stem cells are activated.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-10894126 on NIH RePORTER |
What this research studies
This research focuses on understanding the basic cellular processes that control gene expression in mammalian tissues, particularly during development and regeneration. By examining how nascent transcription and RNA stability affect mRNA levels, the study aims to uncover the mechanisms that regulate gene activity in specific cell types within their natural environment. Using skin as a model, researchers will analyze how these processes change during the activation and differentiation of adult tissue stem cells, specifically in hair follicles. This approach allows for a deeper understanding of gene regulation without isolating cells from their tissues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions affecting tissue development or regeneration, particularly those over the age of 21.
Not a fit: Patients with acute conditions unrelated to tissue biology or gene expression regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into tissue regeneration and potential therapies for conditions related to gene expression dysregulation.
How similar studies have performed: Other research has shown success in understanding gene regulation mechanisms, but this specific approach using in vivo models is relatively novel.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Tumbar, Tudorita — Cornell University
- Study coordinator: Tumbar, Tudorita
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.