Investigating how gene expression is controlled during early development
Equipment Supplement 2R35GM128680: Exploring the connections between translation and mRNA decay
This study is looking at how certain proteins in fruit flies help control the way genes are turned on and off during early development, which could help us understand similar processes in humans.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11097657 on NIH RePORTER |
What this research studies
This research explores the complex interactions between different regulatory pathways that control gene expression, particularly focusing on mRNA decay and translation. Using the fruit fly Drosophila melanogaster as a model organism, the team will study the early stages of development, specifically how maternal RNA binding proteins are regulated and degraded during the maternal-to-zygotic transition. The research aims to uncover the mechanisms behind these processes and their implications for gene regulation. By understanding these fundamental biological processes, the research could provide insights into similar mechanisms in humans.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with genetic disorders or cancers related to gene expression dysregulation.
Not a fit: Patients with conditions unrelated to gene expression or those not affected by developmental processes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of gene regulation, which may have implications for treating various cancers and developmental disorders.
How similar studies have performed: Other research has shown success in understanding gene regulation through similar approaches, indicating that this line of investigation is promising.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Rissland, Olivia Selfridge — University of Colorado Denver
- Study coordinator: Rissland, Olivia Selfridge
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.