Investigating how gene changes affect pain signaling
Abnormal Gene Splicing in Neuropathic Pain
['FUNDING_OTHER'] · NORTH CAROLINA STATE UNIVERSITY RALEIGH · NIH-10786139
This study is looking at how changes in a specific gene related to pain might affect how well pain medications work for people with nerve pain, with the goal of finding better ways to help those who don’t get enough relief from their treatments.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTH CAROLINA STATE UNIVERSITY RALEIGH (nih funded) |
| Locations | 1 site (RALEIGH, UNITED STATES) |
| Trial ID | NIH-10786139 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how the Cacna1b gene, which is crucial for pain signaling, is altered in patients with neuropathic pain. The study examines how different versions of the gene, created through a process called alternative splicing, affect the effectiveness of pain medications like morphine. By analyzing genetic changes in nerve cells after injury, the research aims to uncover why some patients experience reduced pain relief from standard treatments. The findings could lead to new strategies for improving pain management in those suffering from neuropathic pain.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from neuropathic pain, particularly those who have not responded well to traditional pain medications.
Not a fit: Patients with acute pain conditions or those not experiencing neuropathic pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective pain relief options for patients with neuropathic pain.
How similar studies have performed: Previous research has shown promise in understanding gene splicing and its impact on pain management, suggesting that this approach could yield valuable insights.
Where this research is happening
RALEIGH, UNITED STATES
- NORTH CAROLINA STATE UNIVERSITY RALEIGH — RALEIGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LOPEZ SOTO, EDUARDO JAVIER — NORTH CAROLINA STATE UNIVERSITY RALEIGH
- Study coordinator: LOPEZ SOTO, EDUARDO JAVIER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.