Investigating how GCN2 affects stem cell growth and blood vessel cell function
Official title: The role of GCN2 in human induced pluripotent stem cell maintenance, differentiation and endothelial cell function
Funded at University of Illinois at Chicago · NIH-10903341 · Data updated 2026-11-12
This study is looking at how a protein called GCN2 helps stem cells turn into blood vessel cells, which is important for healthy blood flow, and it could help scientists find better ways to use stem cells for treatments.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | September 30, 2024 |
| Project end | September 29, 2026 |
| Funding year | 2024 |
| Award (this year) | $45,708 |
| NIH project number | 1F31HL170726-01A1 |
| Project ID | NIH-10903341 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with conditions related to blood vessel function or those interested in stem cell therapies.
✕Less likely to help
Patients with stable blood vessel function or those not interested in stem cell research may not receive direct benefits from this research.
What this research studies
This research explores the role of the GCN2 protein in maintaining and differentiating human induced pluripotent stem cells (hiPSCs) into endothelial cells, which are crucial for blood vessel function. By examining how GCN2 responds to amino acid availability, the study aims to understand its impact on cell growth and differentiation processes. The researchers will utilize advanced techniques, including CRISPR gene editing and ribosome footprinting, to analyze the effects of GCN2 on stem cell behavior and function. This could lead to insights into how to better manipulate stem cells for therapeutic purposes.
Why it matters
Potential benefit: If successful, this research could enhance the understanding of stem cell biology and improve strategies for regenerative medicine, particularly in vascular diseases.
How similar studies have gone: Previous research has shown promising results in understanding the role of similar pathways in stem cell differentiation, suggesting potential for success in this area.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Toboz, Phoenix — University of Illinois at Chicago
- Study coordinator: Toboz, Phoenix
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.