Investigating how GATA2 affects the development of natural killer cells
Official title: GATA2-TGF beta-TAL1 pathway as a critical mediator of NK Cell development
Funded at Medical College of Wisconsin · NIH-11072171 · Data updated 2026-11-12
This study is looking at how a gene called GATA2 affects the growth and function of important immune cells called natural killer (NK) cells, and it’s for patients with GATA2 mutations who can help by sharing samples to better understand how these changes can lead to immune problems and bone marrow issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | December 27, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $729,047 |
| NIH project number | 1R01AI183571-01A1 |
| Project ID | NIH-11072171 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are individuals with GATA2 mutations or related immune system disorders.
✕Less likely to help
Patients without GATA2 mutations or those not affected by NK cell dysfunction may not benefit from this research.
What this research studies
This research focuses on understanding the role of the GATA2 gene in the development of natural killer (NK) cells, which are crucial for the immune system. It explores a newly identified network involving GATA2, TGF-beta, and TAL1 that influences NK cell development and function. By analyzing genetic data from patients with GATA2 mutations, the research aims to uncover mechanisms that lead to immune system disorders and bone marrow failure. Patients may contribute to this research by providing samples that help identify how these genetic factors affect NK cell behavior.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for immune disorders and improve therapies for conditions related to NK cell dysfunction.
How similar studies have gone: Previous research has shown promising results in understanding the role of transcription factors in immune cell development, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Malarkannan, Subramaniam — Medical College of Wisconsin
- Study coordinator: Malarkannan, Subramaniam
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.