Investigating how gasdermins affect brain cell activation and degeneration in ALS and frontotemporal dementia
The role of gasdermins in microglial activation and neurodegeneration in ALS/FTD
This study is looking at how a protein called gasdermin-D affects brain cells that help keep our brains healthy, specifically in people with ALS and frontotemporal dementia, to find new ways to help improve their condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11032726 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of a protein called gasdermin-D in the activation of microglial cells, which are crucial for brain health, in the context of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The study uses animal models to observe how changes in gasdermin-D levels impact neurodegeneration and disease progression. By examining these mechanisms, the research aims to uncover potential therapeutic targets that could improve outcomes for patients with these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with amyotrophic lateral sclerosis or frontotemporal dementia.
Not a fit: Patients with other neurodegenerative diseases not related to ALS or FTD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or alter the progression of ALS and FTD.
How similar studies have performed: Previous research has shown promising results in understanding microglial activation in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Harvard Medical School — Boston, United States (Active)
Researchers
- Principal investigator: Gunner, Georgia — Harvard Medical School
- Study coordinator: Gunner, Georgia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.