Investigating how GAS6/Axl signaling contributes to high blood pressure
A Role of GAS6/Axl Signaling in the Development of Essential Hypertension
This study is looking at how certain proteins might affect high blood pressure in U.S. Veterans by examining immune cells and their responses, which could help us find new ways to treat hypertension.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ralph H Johnson VA Medical Center NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project ID | NIH-10911150 on NIH RePORTER |
What this research studies
This research explores the role of a specific signaling pathway involving GAS6 and Axl proteins in the development of essential hypertension, particularly among U.S. Veterans. By utilizing advanced techniques like single-cell RNA sequencing, the study aims to identify how certain immune cells, known as dendritic cells, may contribute to inflammation and high blood pressure. The research will involve exposing human immune cells to various stimuli to assess their response and the mechanisms behind hypertension. This could lead to a better understanding of the causes of high blood pressure and potential new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include U.S. Veterans aged 21 and older who are experiencing essential hypertension.
Not a fit: Patients who do not have hypertension or are under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for managing and treating essential hypertension.
How similar studies have performed: Previous research has shown promising results in understanding the immune system's role in hypertension, suggesting that this approach could yield valuable insights.
Where this research is happening
Charleston, United States
- Ralph H Johnson VA Medical Center — Charleston, United States (Active)
Researchers
- Principal investigator: Van Beusecum, Justin Pieter — Ralph H Johnson VA Medical Center
- Study coordinator: Van Beusecum, Justin Pieter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.