Investigating how GARP proteins affect the formation of light-sensitive structures in the retina
Official title: Understanding the Role of GARP Proteins in Rod Outer Segment Disc Formation and Retinal Degeneration
Funded at University of Michigan at Ann Arbor · NIH-10908297 · Data updated 2026-11-12
This study is looking at how certain proteins called GARP help keep the light-sensing cells in your eyes healthy, which could help us understand and find new ways to treat inherited eye diseases that cause vision loss.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | August 26, 2023 |
| Project end | August 25, 2026 |
| Funding year | 2024 |
| Award (this year) | $81,592 |
| NIH project number | 5F32EY034760-02 |
| Project ID | NIH-10908297 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with inherited retinal degenerations or those at risk for such conditions.
✕Less likely to help
Patients with retinal degeneration caused by non-genetic factors may not benefit from this research.
What this research studies
This research focuses on understanding the role of GARP proteins in the formation and maintenance of disc membranes in the outer segments of photoreceptor neurons in the retina. By studying how these proteins contribute to the health of photoreceptors, the research aims to uncover the mechanisms behind inherited retinal degeneration. The approach involves genetic studies in mice to observe the effects of GARP protein ablation on disc synthesis and overall retinal health. The findings could lead to insights into potential therapeutic targets for retinal diseases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for inherited retinal degenerations, potentially restoring vision or slowing disease progression.
How similar studies have gone: Previous research has shown promising results in understanding the role of proteins in retinal health, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Naylor, Molly — University of Michigan at Ann Arbor
- Study coordinator: Naylor, Molly
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.