Investigating how GABAA receptors affect anesthesia and brain activity
GABAA receptors: function, physiology and involvement in anesthesia
This study is looking at how different medicines, like anesthetics, affect a part of the brain that helps control sleep and relaxation, with the goal of finding safer ways to manage anesthesia and help patients recover better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11088778 on NIH RePORTER |
What this research studies
This research focuses on the GABAA receptor, a key player in brain activity and anesthesia. It aims to understand how various compounds, including anesthetics and neuroactive steroids, influence the functioning of these receptors. By examining the kinetics and modulation of GABAA receptors, the research seeks to improve anesthesia management and recovery. Patients may benefit from insights into safer sedation methods and better control over anesthesia effects.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals scheduled for surgeries requiring anesthesia.
Not a fit: Patients who do not require anesthesia or are not undergoing surgical procedures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective anesthesia practices for patients undergoing surgical procedures.
How similar studies have performed: Previous research has shown promising results in understanding GABAA receptor modulation, indicating potential for significant advancements in anesthesia practices.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Akk, Gustav — Washington University
- Study coordinator: Akk, Gustav
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.