Investigating how G protein coupled receptors work and signal in the body.
Official title: G protein coupled receptor structure, dynamics, and signaling.
Funded at Stanford University · NIH-11086059 · Data updated 2026-11-12
This study is looking at special proteins in our bodies that help send signals related to diseases like Alzheimer's and heart problems, to find out how different medicines can change their behavior and potentially lead to better treatments for these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | May 15, 2024 |
| Project end | April 30, 2032 |
| Funding year | 2025 |
| Award (this year) | $627,837 |
| NIH project number | 5R35NS137408-02 |
| Project ID | NIH-11086059 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related neurological conditions.
✕Less likely to help
Patients with conditions unrelated to GPCR signaling or those not diagnosed with any of the targeted diseases may not benefit from this research.
What this research studies
This research focuses on G protein coupled receptors (GPCRs), which are crucial for transmitting signals in the body related to various diseases, including Alzheimer's and cardiovascular disorders. The project aims to understand the complex behaviors of these receptors, including how they can activate different signaling pathways and their potential as therapeutic targets. By using advanced biophysical methods, the research will explore how different drugs can interact with GPCRs to either activate or inhibit their functions. This knowledge could lead to the development of more effective treatments for a range of conditions.
Why it matters
Potential benefit: If successful, this research could lead to new and more effective therapies for diseases like Alzheimer's and other neurological and cardiovascular disorders.
How similar studies have gone: Previous research has shown promising results in understanding GPCR signaling, indicating that this approach has potential for significant advancements in treatment.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Kobilka, Brian K — Stanford University
- Study coordinator: Kobilka, Brian K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.