Investigating how fungi affect health in the gut
Official title: Understanding the molecular mechanisms regulating fungal colonization and disease in the mammalian intestinal niche
Funded at Sloan-Kettering Inst Can Research · NIH-11061757 · Data updated 2026-11-12
This study is looking at how certain fungi, like Candida, interact with the gut and how our immune system responds, especially in people who have had blood cell transplants, to find better ways to prevent infections in those at risk.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $2,450,410 |
| NIH project number | 5P01AI179406-02 |
| Project ID | NIH-11061757 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients who have undergone hematopoietic cell transplantation and are at risk for Candida infections.
✕Less likely to help
Patients without a history of fungal infections or those who are not immunocompromised may not benefit from this research.
What this research studies
This research explores the complex interactions between fungi, specifically Candida species, and the human gastrointestinal system. It aims to understand how these fungi colonize the gut and the immune responses that can prevent or promote infections. By studying patients with hematopoietic cell transplants and using experimental models, the research seeks to identify the molecular and cellular factors that influence fungal colonization and its potential to cause serious illness. The findings could lead to new strategies for preventing fungal infections in vulnerable populations.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for life-threatening fungal infections in patients with compromised immune systems.
How similar studies have gone: Previous research has shown promising results in understanding fungal colonization and its implications for health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Hohl, Tobias M — Sloan-Kettering Inst Can Research
- Study coordinator: Hohl, Tobias M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.