Investigating how fructose affects salt-sensitive high blood pressure
The role of the proximal nephron in salt-sensitive hypertension
['FUNDING_R01'] · CASE WESTERN RESERVE UNIVERSITY · NIH-10744192
This study is looking at how eating a lot of sugar from things like soda might affect people with high blood pressure, especially those who are sensitive to salt, to help find better ways to manage their condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10744192 on ClinicalTrials.gov |
What this research studies
This research explores the connection between high fructose consumption and salt-sensitive hypertension, a condition affecting millions of Americans. It examines how fructose influences the proximal nephron's ability to reabsorb sodium and its interaction with angiotensin II, a hormone that regulates blood pressure. The study aims to understand the mechanisms behind fructose-induced hypertension, particularly focusing on oxidative stress and protease activity in the kidneys. By analyzing these processes, the research seeks to uncover potential therapeutic targets for managing hypertension linked to high fructose intake.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with salt-sensitive hypertension, particularly those who consume high amounts of fructose.
Not a fit: Patients who do not have hypertension or those whose condition is not influenced by dietary factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating salt-sensitive hypertension, particularly in individuals with high fructose diets.
How similar studies have performed: Previous research has indicated a link between dietary factors and hypertension, suggesting that this approach could yield valuable insights, although the specific focus on fructose and the proximal nephron is relatively novel.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GARVIN, JEFFREY L. — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: GARVIN, JEFFREY L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: cardiovascular disorder, Cardiovascular Diseases, diabetes, Diabetes Mellitus, Disorder