Investigating how fragile X premutation affects children's cognitive and behavioral skills
Official title: Association of the Fragile X Premutation with Cognitive and Behavioral Skills in Children
Funded at Queens College · NIH-10909898 · Data updated 2026-11-12
This study is looking at how a specific genetic change related to fragile X syndrome affects the thinking and behavior of children who have it, to see if they face more challenges than kids without this change.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Queens College NIH-funded |
| Lab location | 1 site (Flushing, United States) |
| Project start | September 1, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $587,612 |
| NIH project number | 5R01HD102429-04 |
| Project ID | NIH-10909898 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-21 who have inherited the fragile X premutation from their mothers.
✕Less likely to help
Patients who do not carry the fragile X premutation or are outside the age range of 0-21 may not benefit from this research.
What this research studies
This research aims to understand the impact of the fragile X premutation on the cognitive and behavioral development of children. It focuses on children who inherit a specific genetic variant associated with fragile X syndrome, which may lead to developmental delays, attention deficits, and anxiety. The study will rigorously assess these children to determine if the premutation poses significant risks to their development compared to non-carriers. By analyzing various cognitive and behavioral skills, the research seeks to fill a critical gap in knowledge regarding the early effects of this genetic condition.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and early interventions for children affected by the fragile X premutation.
How similar studies have gone: Previous research has indicated potential developmental risks associated with the fragile X premutation, but this study aims to provide more comprehensive and rigorous evidence.
Where this research is happening
-
Queens College
Flushing, United States Active
Researchers
- Principal investigator: Hinton, Veronica J — Queens College
- Study coordinator: Hinton, Veronica J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.