Investigating how FOXO3 affects hearing loss from noise exposure
Foxo3 Mechanisms in Noise Damage
This study is looking at how a specific gene called FOXO3 affects hearing loss caused by loud noises, using mice to see how different versions of this gene might make some animals more or less likely to get hearing damage, which could help us understand hearing loss in people better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10862773 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of the FOXO3 gene in noise-induced hearing loss (NIHL). By studying mice with and without the FOXO3 gene, researchers aim to uncover how genetic variations influence susceptibility to hearing damage from loud sounds. The study employs advanced techniques such as translatome sequencing and CRISPR modifications to explore the mechanisms behind FOXO3's function and its impact on hearing preservation. The findings could lead to better understanding of genetic factors that contribute to hearing loss in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced noise exposure and may have a genetic predisposition to hearing loss.
Not a fit: Patients with hearing loss due to non-genetic factors or those who have not been exposed to significant noise may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating noise-induced hearing loss in individuals at risk.
How similar studies have performed: Previous studies have indicated that genetic factors play a significant role in susceptibility to hearing loss, suggesting that this research builds on established findings.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: White, Patricia M. — University of Rochester
- Study coordinator: White, Patricia M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.