Investigating how FoxO transcription factors affect joint aging and osteoarthritis.
Official title: FoxO transcription factors in joint aging and osteoarthritis pathogenesis
Funded at Scripps Research Institute, the · NIH-11081657 · Data updated 2026-11-12
This study is looking at how certain proteins called FoxO might affect joint health as we age and how they relate to osteoarthritis, with the hope of finding new ways to help keep our joints healthy as we get older.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | May 15, 2018 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $552,396 |
| NIH project number | 5R37AG059418-08 |
| Project ID | NIH-11081657 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing symptoms of osteoarthritis or those at risk due to age-related factors.
✕Less likely to help
Patients who are younger and do not have any symptoms or risk factors for osteoarthritis may not benefit from this research.
What this research studies
This research focuses on understanding the role of FoxO transcription factors in the aging process of joints and the development of osteoarthritis (OA). It aims to uncover how the reduction of FoxO expression in cartilage contributes to the degeneration associated with aging and OA. By examining the mechanisms that regulate FoxO activity in chondrocytes, the study will utilize both in vitro models and cartilage samples to assess how these factors influence joint health. The ultimate goal is to identify potential therapeutic targets to improve joint function and health in aging populations.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or prevent the progression of osteoarthritis in aging individuals.
How similar studies have gone: Previous research has shown promising results in understanding the role of cellular mechanisms in aging and osteoarthritis, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Scripps Research Institute, the
La Jolla, United States Active
Researchers
- Principal investigator: Lotz, Martin K — Scripps Research Institute, the
- Study coordinator: Lotz, Martin K
Related research
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FoxO factors and aging joints: a path toward healthier cartilage
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.