Investigating how FOXO transcription factors affect aging of intervertebral discs
FOXO transcription factors as critical regulators of intervertebral disc aging
This study is looking at how certain proteins called FOXO might affect the health of the discs in your spine as you get older, which could help us find new ways to prevent or treat back pain caused by disc problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10617735 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of FOXO transcription factors in the aging process of intervertebral discs, which are crucial for spinal health. By examining how these factors influence cell homeostasis and viability in the nucleus pulposus of the discs, the research aims to uncover the molecular mechanisms behind intervertebral disc degeneration. The study involves both human samples and mouse models to explore the relationship between FOXO expression and disc health as individuals age. Insights gained could lead to new strategies for preventing or treating chronic low back pain associated with disc degeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults experiencing chronic low back pain, particularly those over 21 years old who may be at risk for intervertebral disc degeneration.
Not a fit: Patients with acute back pain or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or alleviate chronic low back pain caused by intervertebral disc degeneration.
How similar studies have performed: Other research has shown promising results in understanding the role of transcription factors in aging and degeneration, suggesting that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Lotz, Martin K — Scripps Research Institute, the
- Study coordinator: Lotz, Martin K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.