Investigating how formaldehyde and metabolism affect women's heart health
Role of formaldehyde, formate and one-carbon metabolism in the female heart
This study is looking at how pre-menopausal women have special protections against heart disease that might change after menopause, focusing on how certain substances in the body could help keep their hearts healthy, with the goal of finding new ways to support women's heart health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10471171 on NIH RePORTER |
What this research studies
This research explores the unique biological mechanisms that protect pre-menopausal women from cardiovascular diseases, which seem to diminish after menopause. It focuses on the role of formaldehyde and its metabolism in the female heart, examining how higher levels of certain enzymes in women may contribute to heart health. By understanding these processes, the research aims to identify potential therapeutic targets for improving cardiovascular health in women. The study employs a combination of biochemical assays and preclinical models to investigate these metabolic pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research include pre-menopausal and post-menopausal women who are at risk for cardiovascular diseases.
Not a fit: Patients who are male or those who do not have cardiovascular risk factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance heart health in women, particularly around menopause.
How similar studies have performed: Other research has shown promising results in understanding gender differences in cardiovascular health, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Kohr, Mark Jeffrey — Johns Hopkins University
- Study coordinator: Kohr, Mark Jeffrey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.