Investigating how formaldehyde affects DNA and cancer development
Chromatin assembly and formaldehyde toxicity
This study is looking at how formaldehyde, a substance linked to cancer, affects our DNA and the proteins that help control it, to better understand the risks of cancer from being around formaldehyde, which could help patients in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11003297 on NIH RePORTER |
What this research studies
This research explores the effects of formaldehyde, a known carcinogen, on DNA and cellular processes that may lead to cancer. It focuses on how formaldehyde interacts with histone proteins, which are crucial for DNA packaging and gene regulation. By examining the changes in histone acetylation and the formation of DNA adducts, the study aims to uncover the molecular mechanisms behind formaldehyde-induced carcinogenesis. Patients may benefit from insights gained about cancer risks associated with formaldehyde exposure.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of exposure to formaldehyde or those at risk for cancers associated with chemical carcinogens.
Not a fit: Patients who have no history of formaldehyde exposure or are not at risk for related cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for cancers linked to formaldehyde exposure.
How similar studies have performed: Previous research has shown that understanding the molecular mechanisms of carcinogens can lead to significant advancements in cancer prevention and treatment.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Jin, Chunyuan — New York University School of Medicine
- Study coordinator: Jin, Chunyuan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.