Investigating how fluid forces affect uterine serous carcinoma
Official title: Administrative Supplement for the Study of Shear Stress in Uterine Serous Carcinoma
Funded at University of Michigan at Ann Arbor · NIH-11129113 · Data updated 2026-11-12
This study is looking at how the fluid around uterine serous carcinoma (a tough type of endometrial cancer) affects the cancer cells, with the goal of finding new treatment options for patients who are newly diagnosed or have had the cancer come back.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $155,446 |
| NIH project number | 3R37CA282790-02S1 |
| Project ID | NIH-11129113 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women diagnosed with uterine serous carcinoma, particularly those experiencing peritoneal ascites.
✕Less likely to help
Patients with other types of endometrial cancer or those without ascites may not benefit from this research.
What this research studies
This research focuses on uterine serous carcinoma (USC), a challenging type of endometrial cancer that often presents with peritoneal ascites. The study aims to understand how mechanical forces, particularly shear stress from fluid environments like ascites, influence the behavior of USC cells. By examining the molecular mechanisms involved, the research seeks to identify new treatment strategies for patients with both newly diagnosed and recurrent USC. The approach combines advanced techniques from previous studies on similar cancers to explore how these forces may contribute to cancer progression.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatment options that improve outcomes for patients with uterine serous carcinoma.
How similar studies have gone: Previous research has shown success in understanding the role of mechanical forces in other aggressive cancers, suggesting potential for similar breakthroughs in USC.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Mehta, Geeta — University of Michigan at Ann Arbor
- Study coordinator: Mehta, Geeta
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.