Investigating how filopodia help cells move and communicate
The filopodial tip complex in adhesion, migration, and signaling
['FUNDING_R01'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-10441309
This study is looking at tiny parts of cells that help them move and stick to things, focusing on a protein called Myo10 to see how it influences cell behavior in healthy development and cancer, which could help us find better ways to treat cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-10441309 on ClinicalTrials.gov |
What this research studies
This research focuses on filopodia, which are tiny, finger-like extensions of cells that play a crucial role in how cells interact with their environment. The study examines a specific structure at the tips of these filopodia, known as the filopodial tip complex, which is important for cell adhesion, movement, and signaling. By understanding the role of a protein called Myo10 in these processes, the research aims to uncover how it affects cell behavior in both normal development and cancer progression. This could lead to new insights into how cancer spreads and how to potentially target it more effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research include children and young adults with conditions related to cell adhesion or movement, as well as individuals diagnosed with breast cancer.
Not a fit: Patients with conditions unrelated to cell motility or those who are not affected by breast cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers, particularly breast cancer.
How similar studies have performed: Other research has shown promising results in targeting similar cellular mechanisms in cancer treatment, suggesting that this approach could be effective.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHENEY, RICHARD E — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: CHENEY, RICHARD E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Breast Cancer, Cancers, neoplasm/cancer