Investigating how fibrosis affects cancer outcomes in scleroderma patients
Targeting fibrosis to change cancer outcomes
This study is looking at how lung scarring and cancer are connected in people with scleroderma, especially as they get older, and it hopes to find new ways to help improve treatment for these patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11174594 on NIH RePORTER |
What this research studies
This research focuses on understanding the relationship between fibrosis and lung cancer in patients with scleroderma, a chronic autoimmune disease. It explores how aging and the presence of senescent cells contribute to increased fibrosis and cancer risk. The study employs various methodologies, including animal models, to investigate the molecular mechanisms linking fibrosis and cancer progression. By examining specific signaling pathways, the research aims to uncover potential therapeutic targets that could improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with scleroderma, particularly those who are older and at increased risk for lung cancer.
Not a fit: Patients without a diagnosis of scleroderma or those who do not have significant fibrosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce cancer risk and improve survival rates for scleroderma patients.
How similar studies have performed: Previous studies have indicated a strong link between fibrosis and cancer in other contexts, suggesting that this approach may yield valuable insights.
Where this research is happening
Cincinnati, United States
- University of Cincinnati — Cincinnati, United States (Active)
Researchers
- Principal investigator: Breckenridge, Joey Emery — University of Cincinnati
- Study coordinator: Breckenridge, Joey Emery
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.