Investigating how fibrosis affects cancer outcomes in scleroderma patients
Official title: Targeting fibrosis to change cancer outcomes
Funded at University of Cincinnati · NIH-11174594 · Data updated 2026-11-12
This study is looking at how lung scarring and cancer are connected in people with scleroderma, especially as they get older, and it hopes to find new ways to help improve treatment for these patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | August 15, 2023 |
| Project end | August 16, 2028 |
| Funding year | 2024 |
| Award (this year) | $48,960 |
| NIH project number | 5F31CA284547-03 |
| Project ID | NIH-11174594 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with scleroderma, particularly those who are older and at increased risk for lung cancer.
✕Less likely to help
Patients without a diagnosis of scleroderma or those who do not have significant fibrosis may not benefit from this research.
What this research studies
This research focuses on understanding the relationship between fibrosis and lung cancer in patients with scleroderma, a chronic autoimmune disease. It explores how aging and the presence of senescent cells contribute to increased fibrosis and cancer risk. The study employs various methodologies, including animal models, to investigate the molecular mechanisms linking fibrosis and cancer progression. By examining specific signaling pathways, the research aims to uncover potential therapeutic targets that could improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce cancer risk and improve survival rates for scleroderma patients.
How similar studies have gone: Previous studies have indicated a strong link between fibrosis and cancer in other contexts, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Breckenridge, Joey Emery — University of Cincinnati
- Study coordinator: Breckenridge, Joey Emery
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.