Investigating how fibroblast growth factor signaling can protect against pulmonary hypertension caused by low oxygen levels
The protective role of fibroblast growth factor signaling in hypoxia-induced pulmonary hypertension
This study is looking at how a special protein called FGF can help protect blood vessels in people with pulmonary hypertension from damage caused by low oxygen, with the hope of finding new treatments that could improve your health.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10914667 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms behind pulmonary hypertension, particularly how fibroblast growth factor (FGF) signaling can help protect blood vessels from damage caused by low oxygen levels. The principal investigator, Dr. Kel Vin Woo, will explore how FGF signaling affects the behavior of cells in blood vessels and may lead to new therapies using adenovirus to deliver FGF to the affected areas. Patients may benefit from innovative treatments that improve their condition and overall health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary hypertension, particularly those experiencing symptoms related to low oxygen levels.
Not a fit: Patients with pulmonary hypertension not related to hypoxia or those with other underlying conditions that do not involve FGF signaling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve the management and outcomes of pulmonary hypertension.
How similar studies have performed: Previous research has shown promising results in using FGF signaling to mitigate vascular issues, suggesting that this approach may be effective.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Woo, Kelvin — Washington University
- Study coordinator: Woo, Kelvin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.