Investigating how fibroblast-derived laminin affects the blood-brain barrier after brain hemorrhage
Official title: Fibroblast-derived laminin regulates blood-brain barrier integrity and fibroblast biology in hemorrhagic brain
Funded at University of South Florida · NIH-10892263 · Data updated 2026-11-12
This study is looking at how a protein made by certain cells helps heal the blood-brain barrier after a brain bleed, and it's aimed at finding new treatments for people who have had this type of injury.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Florida NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $479,126 |
| NIH project number | 5R01NS134134-02 |
| Project ID | NIH-10892263 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have suffered from an intracerebral hemorrhage or related brain injuries.
✕Less likely to help
Patients with conditions unrelated to brain hemorrhage or those who do not have a compromised blood-brain barrier may not benefit from this research.
What this research studies
This research focuses on understanding the role of fibroblast-derived laminin in repairing the blood-brain barrier (BBB) following intracerebral hemorrhage (ICH). The team will use mouse models to explore how the absence of this protein impacts BBB integrity and inflammation. They will also identify the molecular mechanisms involved in the BBB repair process and how fibroblast behavior is influenced after ICH. By examining these factors, the research aims to develop new therapeutic strategies for patients suffering from ICH.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve recovery and reduce disability for patients who have experienced a brain hemorrhage.
How similar studies have gone: Previous research has shown promising results in understanding the role of various proteins in BBB repair, making this approach both relevant and potentially impactful.
Where this research is happening
-
University of South Florida
Tampa, United States Active
Researchers
- Principal investigator: Yao, Yao — University of South Florida
- Study coordinator: Yao, Yao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.