Investigating how fibrinogen affects Alzheimer's disease
Role of Fibrinogen in Alzheimer's Disease
This study is looking at how a protein called fibrinogen, which helps with blood clotting, interacts with a substance linked to Alzheimer's disease, to see if this connection might cause brain damage and memory problems, with the hope of finding new ways to help people with Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10896372 on NIH RePORTER |
What this research studies
This research explores the relationship between fibrinogen, a protein involved in blood clotting, and Alzheimer's disease (AD). It aims to understand how fibrinogen interacts with beta amyloid (Aβ), a key player in AD, and how this interaction may lead to neuronal damage and cognitive decline. By studying the toxic effects of Aβ/fibrinogen complexes, the research seeks to uncover new mechanisms that contribute to the progression of AD. Patients may benefit from insights that could lead to novel therapeutic strategies targeting these molecular interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those exhibiting early signs of cognitive impairment.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that mitigate the effects of Alzheimer's disease by targeting the harmful interactions between fibrinogen and beta amyloid.
How similar studies have performed: Previous research has shown promising results in understanding the role of vascular factors in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Strickland, Sidney — Rockefeller University
- Study coordinator: Strickland, Sidney
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.