Investigating how FGFR3 affects parathyroid hormone in jaw joint health
The role of FGFR3 in the effects of PTH in the Mandibular Condyle
This study is looking at how a specific protein affects the way a hormone influences the jaw joint, with the hope of finding better treatments for people suffering from jaw pain and problems caused by temporomandibular joint osteoarthritis (TMJ-OA).
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project ID | NIH-10806946 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of FGFR3 in the effects of parathyroid hormone (PTH) on the mandibular condyle, which is part of the jaw joint. The goal is to explore how these interactions can lead to better treatments for temporomandibular joint osteoarthritis (TMJ-OA), a condition that causes pain and dysfunction in the jaw. By studying the biological mechanisms involved, the research aims to develop therapeutic interventions that could help regenerate cartilage and improve joint health. Patients may benefit from findings that translate basic research into clinical applications for managing TMJ disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing symptoms of temporomandibular joint osteoarthritis or related jaw disorders.
Not a fit: Patients with non-degenerative jaw conditions or those not experiencing TMJ-related symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that alleviate pain and restore function in patients suffering from TMJ disorders.
How similar studies have performed: Previous research has shown promise in using similar biological approaches to treat joint degeneration, indicating potential for success in this area.
Where this research is happening
Farmington, United States
- University of Connecticut Sch of Med/dnt — Farmington, United States (Active)
Researchers
- Principal investigator: Dutra, Eliane — University of Connecticut Sch of Med/dnt
- Study coordinator: Dutra, Eliane
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.