Investigating how FGFR signaling affects liver injury and fibrosis
FGFR Signaling in Liver Injury and Fibrosis
This study is looking at how certain proteins in the body, called FGFRs, affect liver scarring in people with ongoing liver damage, and it hopes to find new ways to help treat this condition by understanding how these proteins work with other signals in the body.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11083672 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of Fibroblast Growth Factor Receptors (FGFRs) in the progression of liver fibrosis, a serious condition that can lead to liver failure. The study aims to explore how FGFRs interact with other signaling pathways, particularly the TGF beta pathway, to promote liver damage and fibrosis in patients with chronic liver injury. By examining specific cell types involved in this process, the research seeks to uncover the molecular mechanisms that drive fibrosis, which could lead to new therapeutic strategies. Patients may be involved in providing samples or data to help elucidate these mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from chronic liver injury or fibrosis, particularly those with conditions that may involve FGFR signaling.
Not a fit: Patients with acute liver injury or those without any liver-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reverse liver fibrosis, improving outcomes for patients with chronic liver diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of FGFRs in liver fibrosis, indicating that this approach has potential for significant advancements in treatment.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Mavila, Nirmala — Cedars-Sinai Medical Center
- Study coordinator: Mavila, Nirmala
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.