Investigating how FGF23 and phosphate affect chronic kidney disease
Role of FGF23 and Phosphate in Chronic Kidney Disease
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY AT CHICAGO · NIH-10978219
This study is looking at how a substance called FGF23 and high phosphate levels affect kidney disease and heart health, and it will test a new treatment that might help improve kidney function for people with chronic kidney disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY AT CHICAGO (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-10978219 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the roles of fibroblast growth factor 23 (FGF23) and phosphate levels in the progression of chronic kidney disease (CKD). It aims to explore how excess FGF23 and phosphate can accelerate CKD and lead to serious cardiovascular issues and mortality. The study will utilize animal models to test the effects of an FGFR1 inhibitor, which may help restore normal kidney function and circadian rhythms disrupted by CKD. By identifying new therapeutic approaches, the research seeks to improve outcomes for patients with CKD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic kidney disease, particularly those experiencing elevated levels of FGF23 and phosphate.
Not a fit: Patients with acute kidney injury or those without chronic kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow the progression of chronic kidney disease and reduce associated health risks.
How similar studies have performed: Previous research has shown promising results with similar approaches targeting FGF23 and phosphate in chronic kidney disease models.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY AT CHICAGO — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MARTIN, ALINE C — NORTHWESTERN UNIVERSITY AT CHICAGO
- Study coordinator: MARTIN, ALINE C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.