Investigating how fentanyl and HIV affect brain cells and their interactions.
Opioid and non-opioid receptor mechanisms in neurons and glia underlying fentanyl and HIV comorbidity in the striatum
['FUNDING_R01'] · VIRGINIA COMMONWEALTH UNIVERSITY · NIH-11109684
This study is looking at how fentanyl, a strong pain medication, interacts with HIV in the brain and affects brain cells, with the goal of finding better ways to help people who have both conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VIRGINIA COMMONWEALTH UNIVERSITY (nih funded) |
| Locations | 1 site (RICHMOND, UNITED STATES) |
| Trial ID | NIH-11109684 on ClinicalTrials.gov |
What this research studies
This research explores the complex interactions between fentanyl, a powerful opioid, and HIV in the brain, particularly focusing on how these substances affect neurons and glial cells in the striatum. The study examines the role of both opioid and non-opioid receptors in mediating the effects of fentanyl, including its impact on neuronal activity and inflammation. By using advanced animal models, the research aims to uncover the underlying mechanisms that contribute to neuroHIV and HIV-associated neurocognitive disorders, which could lead to better understanding and treatment options for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living with HIV who are also using opioids, particularly fentanyl.
Not a fit: Patients who are not affected by HIV or do not use opioids may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for individuals with HIV who are also struggling with opioid use, potentially reducing cognitive decline and enhancing quality of life.
How similar studies have performed: While the specific combination of fentanyl and HIV in this context is novel, previous research has shown that understanding receptor mechanisms can lead to significant advancements in treatment strategies.
Where this research is happening
RICHMOND, UNITED STATES
- VIRGINIA COMMONWEALTH UNIVERSITY — RICHMOND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HAUSER, KURT F — VIRGINIA COMMONWEALTH UNIVERSITY
- Study coordinator: HAUSER, KURT F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus