Investigating how faulty DNA repair contributes to lupus
Aberrant DNA Repair and Lupus
This study is looking at how problems with DNA repair might contribute to lupus, a condition that affects many people, and it involves patients helping researchers understand the genetic factors that could lead to better treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-11121092 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of defective DNA repair mechanisms in the development of Systemic Lupus Erythematosus (SLE), an autoimmune disease affecting over a million Americans. The study examines genetic factors, particularly mutations in the POLB gene, and their impact on immune responses and disease progression. By analyzing genetic variants in individuals with lupus, the research aims to uncover the underlying causes of this complex disease and identify potential therapeutic targets. Patients may be involved in genetic studies to help elucidate these mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals of Asian, Hispanic, Native American, and African ancestry who have been diagnosed with Systemic Lupus Erythematosus.
Not a fit: Patients with lupus who do not have genetic predispositions or those from populations not significantly affected by the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for lupus, improving outcomes for patients suffering from this chronic condition.
How similar studies have performed: Previous research has shown promising results in understanding genetic factors in lupus, suggesting that this approach could yield valuable insights.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Sweasy, Joann B. — University of Nebraska Medical Center
- Study coordinator: Sweasy, Joann B.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.